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Snapshots of the dynamic basis of NTSR1 G protein subtype promiscuity
TechnologyMarch 11, 2026

Snapshots of the dynamic basis of NTSR1 G protein subtype promiscuity

G-protein-coupled receptors (GPCRs) are capable of signalling through four families of G protein α subunits. Although hundreds of nucleotide-free GPCR–G protein complex structures have been solved, the mechanism of G protein subtype selectivity remains poorly understood, with recent studies suggesti