3rd March 2026: The Final Puzzle has now been solved and tested successfully.
Those with a particularly keen eye for puzzles and challenges will spend no time at all trying to solve the mysterious 'Final Puzzle' challenge in Resident Evil Requiem, which consists of a bunch of obtuse clues and steps that can be incredibly easy to miss.
Finding these hints and ultimately piecing them together throughout the game is no easy feat by any means, and that's why – up until 2nd March 2026 – we weren't able to solve it. Below, we've detailed all of the Final Puzzle clues, hints, and steps we've found as well as how to solve the Final Puzzle in Resident Evil Requiem.
Also, here's your spoiler warning for the following page! The Final Puzzle's clues span most of Requiem's story, so be careful reading ahead if you've not yet finished your first playthrough.
- Final Puzzle Clue #1, Severed Hand
- Final Puzzle Clue #2, Lead Researcher's Puzzle Box
- Final Puzzle Clue #3, Laser Microscope
- Final Puzzle Clue #5, Grace Ashcroft Blood Analysis Report
- Final Puzzle Clue #6, Toy Uncle Bobblehead
- Final Puzzle Clue #7, Child's Laughter
- Final Puzzle Clue #10, Marie's Doll
- How to solve the Final Puzzle
Resident Evil Requiem Final Puzzle explained
The Final Puzzle is one of many challenges listed in the Resident Evil Requiem's 'Challenges' menu. It's worth 20,000 CP once it's been completed, and your only clue for this particular challenge is as follows:
"Let the sweet pair hear the voice."
Interpret that however you please, but the key things to note here are the mentions of "sweet pair" and "voice".
Now, "sweet pair" seems to be referring to the likes of Emily and Marie. Emily being the young girl Grace is trying to rescue in Requiem, while Marie is suspected to actually be The Girl (before she transformed). That said, there is a Marie Doll that can be collected in-game, and that's our key to bringing the 'sweet pair' together. More on that soon.
As for what the "voice" refers to, this appears to be a laughing sound that can be triggered at the Lead Researcher's Puzzle Box using the below steps.
Resident Evil Requiem Final Puzzle Part 1 - Activating the 'Voice'
Throughout the rest of this page, we've detailed the clues we've found so far (or at least, what we suspect are clues) and how they are related to one another. We also currently suspect that without prior knowledge of the puzzle, it can only be completed in New Game Plus.
Final Puzzle Clue #1, Severed Hand
The first clue that points to the Final Puzzle in Resident Evil Requiem is The Girl's Severed Hand.
Once you escape from the Basement beneath Rhodes Hill Care Center via the elevator, you'll actually shut the elevator on The Girl, forcibly dismembering her hand. Gross. What's even more gross is you can pick up this Severed Hand and add it to your inventory.
Now, as you continue exploring Rhodes Hill Care Center and run into the Laser Microscopes (which allow you to solve puzzles to unlock new recipes), it turns out you can actually place the Severed Hand into one of the Laser Microscopes.
Upon doing so, you'll need to solve one of the minor Laser Microscope puzzles as per usual, but rather than unlocking new recipes for your efforts, something else appears…
You are presented with the message that reads "Let's play" alongside the following code:
'GGC AAG AUA ACG UGU CAU'
What this code means is yet to be revealed, but the following clues help us along a little.
Final Puzzle Clue #2, Lead Researcher's Puzzle Box
After successfully opening the Lead Researcher's Puzzle Box in Rhodes Hill Care Center (which contained the Star Quartz and a Notebook) and scanning the Severed Hand at a Laser Microscope, you are able to input another code despite the Puzzle Box already being unlocked.
With this in mind, we can only assume that the code from the Severed Hand can be translated into a code involving the Sun, Moon, and Star symbols. More on this shortly.
Final Puzzle Clue #3, Laser Microscope
If you look at the side of the Laser Microscope machine in the Blood Lab in Rhodes Hill Care Center, there's a label on the side of this machine that says the following:
Now, hear me out (and thanks is owed to IGN for this!), but given the assumption that the code from the Severed Hand could correlate with the Puzzle Box's Sun, Moon, and Star symbols, folk have done some sleuthing as to how these numbers correlate with those three things.
It just so turns out that the Sun is 150 million miles away from Earth and using that logic, G = Sun.
Once you make your escape from Rhodes Hill Care Center and begin looking for the Helicopter Key, you'll quickly run into an Hourglass you can unscrew from the desk of the VIP Suite.
If you rotate this hourglass and allow it to drain, a code is revealed that reads:
Again, if we're trying to relate these numbers to real-life facts related to the Sun, Moon, and Stars, it just so happens that the Moon is 380,000 kilometers away from Earth.
Using that logic, this means that U = Moon. We just need to work out what 'C' and 'A' mean next.
Final Puzzle Clue #5, Grace Ashcroft Blood Analysis Report
While exploring the facility beneath the Helipad in Rhodes Hill Care Center's grounds (this is where you find the Helicopter Key), you can find a document – Grace Ashcroft Blood Analysis Report – on one of the desks.
Careful perusal of this document reveals that 'C = 4.2 ly', and of course, it just so happens that the closest Star to Earth is 4.2 light years away.
This means that C = Star.
Final Puzzle Clue #6, Toy Uncle Bobblehead
While playing as Leon following the Tyrant boss fight, there's a caged off sports court where you'll find a Toy Uncle Bobblehead that you can kick around.
There's also a basketball hoop lying on the ground in this sports court. If you successfully kick the Uncle Toy Bobblehead through the hoop, you can then interact with the hoop to receive a message: "There's no time for playing around."
After this, head into the back of Kendo's Gun Shop, where you'll find the torso of the Toy Uncle Bobblehead. Interact with it and you'll be told to 'Just ignore A' which we can only assume means we can remove A from the Severed Hand code.
